FLAVOPIRIDOL HYDROCHLORIDE HYDRATE

Code: F3055-25MG D2-231

Application

Flavopiridol hydrochloride hydrate has been used:as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K3...


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€705.00 25MG
€867.15 inc. VAT
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Application

Flavopiridol hydrochloride hydrate has been used:as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblastsas an RNA polymerase inhibitor to study its effects on hepatic cellsas RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo

Biochem/physiol Actions

Flavopiridol hydrochloride is a potent CDK (cyclin-dependent kinase), and a CDC25 phosphatase family inhibitor.

Flavopiridolis a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to light brown
formpowder
Gene Informationhuman ... CDK1(983), CDK2(1017), CDK4(1019), CDK6(1021), CDK7(1022), CDK9(1025)
InChI keyLGMSNQNWOCSPIK-LWHGMNCYSA-N
InChI1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
Quality Level100
SMILES stringOC1=C(C(C=C(C2=C(Cl)C=CC=C2)O3)=O)C3=C([C@H]4CCN(C)C[C@H]4O)C(O)=C1.Cl
solubilityDMSO: >5 mg/mL, H2O: ~2 mg/mL
storage conditiondesiccated
storage temp.2-8°C
Cas Number131740-09-5
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